Top 6 answers on the board . . .
1. Airborne (1993)
So the final race sequence is illogical but you certainly get to see a lot of the City in the movie including a nice Krohn cameo.
2. Eight Men Out (1988)
3. Little Man Tate (1991)Here you get some UC, Miami, OSU and Jody Foster!
4. Fresh Horses (1988)
5. Traffic (2000)
6. Rain Man (1988)
Rain Man would probable not make the list as I do not like Dustin Hoffman or Tom Cruise but I guess it probably has to be included.
In honor of tonight's Oscars, the above are my favorite movies set or filmed in and around the Queen City. Can't say they are always the best films (like Fresh Horses in particular) but there is not a lot out there.
Movie posters from AllPosters.com, MoviePoster.com, and MLive.com